Medisinen ble opprinnelig utviklet i Frankrike til bruk i det franske forsvaret. Den skulle brukes av det franske flyvåpenets soldater, slik at de skulle føle mindre tretthet og klare å konsentrere seg bedre om oppgavene sine.
crizotinib improves levels of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch. Dose reduction can be needed for coadministered medicine which can be predominantly metabolized by CYP3A.
Our proof-based Evaluation of Modafinil capabilities one of a kind references to scientific papers and anecdotal experiences.
modafinil will raise the stage or result of rabeprazole by impacting hepatic enzyme CYP2C19 metabolism. Slight/Significance Unknown. Web impact on pantoprazole steps unidentified because of opposing effects of CYP450 enzymes; check
Keep an eye on Closely (one)istradefylline will increase the stage or influence of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
modafinil will enhance the stage or effect of diazepam buccal by impacting hepatic enzyme CYP2C19 metabolism. Use Warning/Keep an eye on. Potent or average CYP2C19 inhibitors might lower level of diazepam elimination, therefore expanding adverse reactions to diazepam.
Coadministration of encorafenib with sensitive CYP3A4 substrates could end in improved toxicity or diminished efficacy of such agents.
larotrectinib will improve the amount or result of modafinil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.
Absorption: Modafinil is readily absorbed soon after oral administration. It is insoluble in an aqueous Resolution and thus can't be administered intravenously. Most plasma concentration is attained 2 to 4 hrs right after administration.
Limits of Use In OSA, modafinil tablets are indicated to treat excessive sleepiness and never as remedy to the underlying obstruction. If steady constructive airway strain (CPAP) could be the cure of choice for a patient, a maximal effort and hard work to deal with with CPAP for an sufficient time period should be manufactured prior to initiating and during treatment with modafinil tablets for extreme sleepiness. two DOSAGE AND ADMINISTRATION
cannabidiol will enhance the amount or outcome of modafinil by affecting hepatic enzyme CYP2C19 metabolism. Modify Therapy/Keep an eye on Carefully. Take into consideration reducing the dose of sensitive CYP2C19 substrates, as clinically correct, when coadministered with cannabidiol.
Check Intently (one)modafinil will boost the stage or influence of citalopram by affecting hepatic enzyme CYP2C19 metabolism. Use Caution/Keep an eye on. Citalopram twenty mg/day is the utmost encouraged dose for people having CYP2C19 inhibitors because get more info of the risk of QT prolongation.
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In Romania, modafinil is assessed to be a stimulant doping agent and is prohibited in sports competitions.